I'm BLOWING THE WHISTLE on Ozempic

I'm BLOWING THE WHISTLE on Ozempic

Dr. Boz [Annette Bosworth, MD]

0:00 Were you or a loved one harmed by Ompic?

0:02 Get used to hearing those words because class

0:05 action lawsuits are going to be filed any day.

0:08 I'm a doctor and the way some

0:09 of my colleagues are prescribing these drugs scares me.

0:12 In the same way Oxycontton started an opioid epidemic,

0:16 Ompic is starting an epidemic of skinny fat

0:20 people with a metabolic disaster happening inside their body.

0:24 And many, especially older people,

0:26 will not recover from the damage caused by these drugs.

0:30 In this video, I'm going to break down once

0:32 and for all how Ompic and other GLP-1 agonist drugs work,

0:37 the real cost of rapid weight loss when using GLP-1s,

0:40 the only condition where I'd prescribe GLP-1s,

0:43 and how I minimize the risks associated with the drug.

0:47 Starting with how does it work.

0:49 To understand why this drug is dangerous in the wrong hands,

0:53 you have to understand that it's not just a weight loss shot.

0:56 It is a hormone.

0:58 You are injecting a hormone that manipulates the deepest signals in your body.

1:03 These drugs known as GLP-1 agonist didn't start as weight loss miracles.

1:08 They have a history.

1:09 We first started writing prescriptions for a drug called Biata back in 2013.

1:15 It was a diabetes medication intended to manipulate

1:18 how the body sensed fullness and how insulin worked.

1:22 Back then, it didn't cause massive weight loss.

1:25 Maybe one in 20 of my patients would lose weight.

1:28 Fast forward to today and we have drugs

1:30 like ompic called semiglutide or monero called trzepatide.

1:34 These drugs are much more potent.

1:37 Ompic mimics the hormone called GLP-1

1:40 that your body naturally produces in your gut.

1:42 And Mangerro takes it a step further by also mimicking GIP.

1:47 First, they scream at your pancreas to stop releasing

1:51 glucagon and to start increasing a bit more insulin.

1:54 Both of these lower your blood sugar, and that's great if you're a diabetic.

1:58 But the second thing it does is paralyze your gut.

2:02 Yeah, it slows down that gastric emptying,

2:04 so food sits in your stomach longer, making you feel full.

2:08 Third, and this is the big one, they hijack your brain,

2:12 they act on satiety centers in your brain to kill your appetite

2:16 and turn off that reward signal that you get from food.

2:19 It sounds like the perfect solution, right?

2:22 You don't want to eat, so you lose weight.

2:24 But there are hidden costs to the mechanism that nobody's talking about.

2:28 When you force a body to stop eating through chemical starvation,

2:33 but you don't fix the underlying metabolic brokenness,

2:36 you're creating a disaster.

2:38 Second, we have the real cost of rapid weight loss.

2:42 All right, the headlines have been screaming about the pounds dropping off,

2:45 but they don't tell you what kind of weight is being lost.

2:49 When you starve a body that is insulin resistant,

2:52 and make no mistake, if you are overweight, you are insulin resistant.

2:57 Your body is in crisis.

2:59 When you take a drug that forces you into a severe calorie deficit,

3:04 your body has to find energy somewhere.

3:06 If your insulin is high,

3:08 your body cannot easily access your fat stores where there's lots of energy.

3:13 That high insulin locks the doors to your fat cells.

3:16 So, if you aren't eating and you can't get to the fat,

3:21 where does your body get the fuel from?

3:23 Well, it burns your furniture to heat the house.

3:26 Yes, it burns your muscle.

3:28 Data shows that when people take these drugs without a specific intervention,

3:32 roughly onethird of the weight they lose is lean mass.

3:37 That's your muscle or your bone density.

3:39 In some cases, you can have about 50/50 split with fat and muscle loss.

3:45 But this is catastrophic.

3:46 That is not good.

3:47 By now, you've seen patients who develop ompic face,

3:51 which is really just facial muscle wasting.

3:54 It's a sign of what's happening all over the body.

3:58 They are becoming skinny fat.

4:00 They weigh less on the scale,

4:02 but their metabolic rate has crashed because they are

4:05 cannibalizing the very muscle tissue that drives their metabolism.

4:09 For my older patients, this is a death sentence.

4:12 Sarcopenia, the other word for muscle wasting,

4:14 is one of the leading causes of frailty and death in the elderly.

4:18 If you are 60 years old and you rapidly lose

4:22 15 pounds of muscle to drop 15 pounds of fat,

4:26 you might never get that muscle tissue back

4:28 and you've just accelerated your aging process by a decade.

4:32 And the tragedy is many people take these drugs and don't even lose the weight.

4:38 Let me tell you about a patient named Rebecca.

4:40 Her story perfectly illustrates why prescribing

4:43 this drug without fixing the metabolism is malpractice.

4:47 Rebecca had struggled with her weight for decades.

4:49 She had tried everything.

4:51 She had even had a lap band surgery years ago,

4:54 which mechanically restricted her food intake.

4:57 She lost some weight, but her insulin resistance smoldered in the background.

5:02 Eventually, she had to have that band removed

5:04 and the weight came back with a vengeance.

5:07 Desperate, she went to her doctor who prescribed

5:10 her OMIC and she injected this drug for 12 weeks.

5:14 She did exactly what she was told.

5:16 And do you know how much weight she lost?

5:18 Yeah.

5:18 A big goose egg.

5:19 Zero.

5:20 Not a single pound.

5:22 How is it possible?

5:23 How can you take the strongest weight loss drug on the market,

5:27 a hormone that manipulates the things we've talked about, and not lose weight?

5:31 Well, it's because of another hormone, insulin.

5:34 Rebecca's body was producing massive amounts of insulin,

5:37 a problem that started back when she was a teenager.

5:41 Insulin is the storage hormone.

5:43 It tells your body to store energy and not burn it.

5:46 Even though Ompic was screaming at her brain to stop eating,

5:50 her insulin levels were so high that her body refused to let go

5:55 of any of the fat and the drug could not overpower her endocrine error.

5:59 In fact, the drug stimulates the pancreas to make a little more insulin.

6:04 This stimulus is a risk that we are willing to take with a type 2 diabetic.

6:09 Their insulin is not working right.

6:10 But for someone like Rebecca,

6:12 who is already swimming in a sea of excess insulin,

6:15 adding the drug that squeezes the pancreas

6:18 harder is like throwing gasoline on the fire.

6:20 She didn't need more beta cell stimulation to make insulin.

6:24 She needed to lower her insulin.

6:26 And this is the epidemic that I'm worried about.

6:29 Patients like Rebecca are being prescribed a drug that costs a fortune,

6:33 risks their muscle mass, and doesn't even work because the doctor

6:37 skipped the root cause, insulin resistance.

6:40 So, do I hate these drugs?

6:42 No.

6:43 I actually think they can be a powerful tool,

6:46 but if and only if the patient earns the right to use them.

6:51 Yeah, I have a rule.

6:53 You must have a bed of ketones in your chemistry before you add this hormone.

6:58 You cannot take a metabolic shortcut.

7:01 If you're burning glucose or sugar for fuel and you add ozic,

7:06 you're starving the sugar burner.

7:08 Like that's misery.

7:10 This is where the nausea and the fatigue and the muscle loss come from.

7:14 But if you transition your body to burn fat for fuel first,

7:18 if you get into ketosis, you change the game.

7:22 Ketones are a clean fuel for your brain.

7:25 They also protect your muscles and they lower the inflammation.

7:29 I have another patient named Ian.

7:31 He's nearly 70 years old and has been insulin resistant for at least 60 years.

7:36 But unlike the typical patient,

7:38 Ian spent a year learning how to eat a ketogenic diet.

7:42 He learned how to lower his carbohydrates,

7:44 shorten his eating window, and get his body to produce ketones.

7:48 When we looked at Ian's numbers,

7:50 the blood sugars were stable, but he had hit a plateau.

7:54 Now, he had done the work.

7:55 He was metabolically flexible, using either fat or glucose,

7:59 and switching between the two.

8:01 This is when we added a low dose of GLP-1 agonist and the results were striking.

8:08 Because his body had already been fueled by ketones,

8:12 the drug didn't make him sick.

8:14 And again, we were using a very tiny dose.

8:17 It didn't eat his muscles.

8:19 Instead, it acted like a turbocharger for his fat loss.

8:24 I call it it put the fat forward.

8:26 It also quieted the food noise in his brain,

8:29 allowing him to fast a little longer and deeper,

8:32 which naturally lowered his insulin even further.

8:35 If you're going to use these drugs, or if you're currently on them,

8:40 you need to follow a protocol that protects

8:43 your body from the skinny fat disaster.

8:45 First, you got to check your numbers.

8:48 You need to know what your Dr.

8:49 Bos ratio is.

8:51 This is your glucose divided by your ketones.

8:54 And if your ratio is above 100, you are high risk for insulin resistance.

8:58 You're in storage mode.

9:00 You need to get that ratio under 80 and ideally under 40 to be

9:04 in the true fat burning state where your body

9:08 will harvest the fat instead of the muscle.

9:11 Second, you must prioritize protein.

9:14 The current data is clear.

9:15 If you do not eat enough protein and if

9:17 you don't do resistance training while on these drugs, you will lose muscle.

9:22 You need to be eating two solid ketogenic meals

9:25 a day to signal your body that it is not starving.

9:29 The third one is stop grazing.

9:31 This is the worst thing that I see people do while on ompic.

9:35 They eat small amounts of meals,

9:37 especially high in carbohydrates, and that keeps that insulin high,

9:41 dripping into their system and preventing

9:43 them from ever accessing the fat stores.

9:45 Rebecca, our patient we mentioned earlier, finally started to lose weight.

9:50 Not when she took the drug alone,

9:52 but when she switched to the sardine challenge and she

9:54 shortened her eating window to just a few hours a day.

9:57 If you want to know the rules for that sardine challenge, click here.

10:00 I will see you in the next video.

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